Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P102 | P102-42 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 30 |
| 3 | 3TC+AZT+EFV+IDV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L | L10I, N37H, R41K, L63T, I64V, I93L |
| >P102-42| H07 | codons 1-99 | clone H07 PQITLWQRPIVTIKIGGQLKGALLDTGADDTILEEMHLPGKWTPKMVGGIGGFIKVRQYD QIPVEICGHKAIGTVLVGPTPVNIIGRNLMTQLGCTLNF >P102-42| H01 | codons 1-99 | clone H01 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMHLPGKWKPKLIGGIGGFIKVRQYD QITVEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >P102-42| H04 | codons 1-99 | clone H04 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMHLPGKWKPKIIGGIGGFIKVRQYD QITVEICGHKAIGTVLVGPTPVNTIGRSLLAQLGCTLNF >P102-42| H03 | codons 1-99 | clone H03 PQITLWQRPIVTIKIGGQLKEALLDTGADDTILEEMHLPGKWKPKMVGGIGGFIKIRQYD QIPVETCGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P102-42| H08 | codons 1-99 | clone H08 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMHLPGKWKPKLIGGIGGFIKVRQYD QITVEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P102-42| H05 | codons 1-99 | clone H05 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMHLPGKWKPKLIGGIGGFIKVRQYD QITVEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P102-42| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMHLPGKWKPKLIGGIGGFIKVRQYD QITVEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | L100I, K103N | K20R, K43Q, E44D, V118I, D123E, I135T, D177E, G196E, E203K, Q207E, R211Q |
| >P102-42| H08 | codons 1-229 | clone H08 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW >P102-42| H03 | codons 1-229 | clone H03 PISPIETVPVKLKPGMDGPRVKQWPLAEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRHQYNVLPQGWKGSPAIFQSSMTKILEPFIKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW >P102-42| H07 | codons 1-229 | clone H07 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW >P102-42| H04 | codons 1-229 | clone H04 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEIRTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDGLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW >P102-42| H01 | codons 1-229 | clone H01 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW >P102-42| H05 | codons 1-229 | clone H05 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW >P102-42| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |