<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB4-P102 P102-42 U.S. 1998 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 3TC+AZT 8
2 3TC+AZT+EFV 30
3 3TC+AZT+EFV+IDV 12

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L   L10I, N37H, R41K, L63T, I64V, I93L  
>P102-42| H07 | codons 1-99 | clone H07
PQITLWQRPIVTIKIGGQLKGALLDTGADDTILEEMHLPGKWTPKMVGGIGGFIKVRQYD
QIPVEICGHKAIGTVLVGPTPVNIIGRNLMTQLGCTLNF
>P102-42| H01 | codons 1-99 | clone H01
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMHLPGKWKPKLIGGIGGFIKVRQYD
QITVEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>P102-42| H04 | codons 1-99 | clone H04
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMHLPGKWKPKIIGGIGGFIKVRQYD
QITVEICGHKAIGTVLVGPTPVNTIGRSLLAQLGCTLNF
>P102-42| H03 | codons 1-99 | clone H03
PQITLWQRPIVTIKIGGQLKEALLDTGADDTILEEMHLPGKWKPKMVGGIGGFIKIRQYD
QIPVETCGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>P102-42| H08 | codons 1-99 | clone H08
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMHLPGKWKPKLIGGIGGFIKVRQYD
QITVEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>P102-42| H05 | codons 1-99 | clone H05
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMHLPGKWKPKLIGGIGGFIKVRQYD
QITVEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>P102-42| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMHLPGKWKPKLIGGIGGFIKVRQYD
QITVEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y   L100I, K103N   K20R, K43Q, E44D, V118I, D123E, I135T, D177E, G196E, E203K, Q207E, R211Q  
>P102-42| H08 | codons 1-229 | clone H08
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW
>P102-42| H03 | codons 1-229 | clone H03
PISPIETVPVKLKPGMDGPRVKQWPLAEEKIKALVEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRHQYNVLPQGWKGSPAIFQSSMTKILEPFIKQNPEIVI
YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW
>P102-42| H07 | codons 1-229 | clone H07
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW
>P102-42| H04 | codons 1-229 | clone H04
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEIRTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDGLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW
>P102-42| H01 | codons 1-229 | clone H01
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW
>P102-42| H05 | codons 1-229 | clone H05
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW
>P102-42| codons 1-229
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005