Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P101 | P101-72 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 20 |
| 3 | 3TC+AZT+EFV+IDV | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82F | L24I | L10I, M36I, I62V, L63T, I93L |
| >P101-72| D11 | codons 1-99 | clone D11 PQVTLWQRPIVTIKIGGQLKEALIDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD QVTIEICGHKAIGTVLVGPTPVDIIGRNLLTQLGCTLNF >P101-72| D12 | codons 1-99 | clone D12 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEINLPGKWKPRIIGGIGGFIKVRQYD QVTIEICGHKAIGTVLVGPTPFNIIGRNLLTQLGCTLNF >P101-72| D10 | codons 1-99 | clone D10 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVTIEICGHKAIGTVLVGPTPFNIIGRNLLTQLGCTLNF >P101-72| D08 | codons 1-99 | clone D08 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD QVTIEICGHKAIGTVLVGPTPFNIIGRNILTQLGCTLNF >P101-72| D04 | codons 1-99 | clone D04 PQITLWQRPIITIKIGGQLKEALIDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD QVTIEVRGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P101-72| D06 | codons 1-99 | clone D06 PQITLWQRPIVTIEIGGQLKEALLDTGADDTVLEEINLPGRWKPKLIGGIGGFIKVRQYD QVTIEICGHKAIGTVLVGPTPFNIIGRNLLTQLGCTLNF >P101-72| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD QVTIEICGHKAIGTVLVGPTPFNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | P225H | R83K, I135L, Q174H, Q207K, R211S |
| >P101-72| D10 | codons 1-229 | clone D10 PISPIEAVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRKHLLSWGFTTPDKKHQKEHPFLW >P101-72| D11 | codons 1-229 | clone D11 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRKHLLSWGFTTPDKKHQKEHPFLW >P101-72| D12 | codons 1-229 | clone D12 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRKHLLSWGFTTPDKKHQKEHPFLW >P101-72| D04 | codons 1-229 | clone D04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYMDDLYVGSDLEIGRHRTKIEELRKHLLSWGFTTPDKKHQKEHPFLW >P101-72| D06 | codons 1-229 | clone D06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENLYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRKHLLSWGFTTPDKKHQKEHPFLW >P101-72| D08 | codons 1-229 | clone D08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMVKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGSKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYDVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYMDDSYVGSDLEIGQHRTKIEELRKHLLSWGFTTPDKKHQKEHPFLW >P101-72| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRKHLLSWGFTTPDKKHQKEHPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |