Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P98 | P98-33 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV+IDV | 33 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, M36I, R41K, I62V, L63H |
| >P98-33| G03 | codons 1-99 | clone G03 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P98-33| G02 | codons 1-99 | clone G02 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P98-33| G04 | codons 1-99 | clone G04 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P98-33| G08 | codons 1-99 | clone G08 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P98-33| G07 | codons 1-99 | clone G07 PQITLWQRPLATIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD RIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P98-33| G09 | codons 1-99 | clone G09 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P98-33| G11 | codons 1-99 | clone G11 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P98-33| G06 | codons 1-99 | clone G06 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIPIEVCGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF >P98-33| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | K103N | P225H | D123E, E138A, I178M, V179I |
| >P98-33| G11 | codons 1-229 | clone G11 PISPIETVPVKLKPGMDGPKAKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKRHQKEPPFLW >P98-33| G09 | codons 1-229 | clone G09 PISPVETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRTKIEELGQHLLRWGFTTPDKKHQKEHPFLW >P98-33| G07 | codons 1-229 | clone G07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGLPAIFQSSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P98-33| G02 | codons 1-229 | clone G02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPEDPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P98-33| G04 | codons 1-229 | clone G04 PVSPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMNDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P98-33| G06 | codons 1-229 | clone G06 PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P98-33| G03 | codons 1-229 | clone G03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVGICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P98-33| G08 | codons 1-229 | clone G08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKNHQKEPPFLW >P98-33| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |