Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P91 | P91-98 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 96 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10V, I15V, E35D, N37D, L63P, A71V, I93L |
| >P91-98| E05 | codons 1-99 | clone E05 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFVKVKQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF >P91-98| E01 | codons 1-99 | clone E01 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF >P91-98| E03 | codons 1-99 | clone E03 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEDMDLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF >P91-98| E02 | codons 1-99 | clone E02 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF >P91-98| E07 | codons 1-99 | clone E07 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEDMDLPGRWKPKVIGGIGGFAKVKQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF >P91-98| E04 | codons 1-99 | clone E04 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF >P91-98| codons 1-99 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEDMDLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | S48T, K122E, S162C |
| >P91-98| E07 | codons 1-229 | clone E07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFITPDKKHQKEHPFLW >P91-98| E05 | codons 1-229 | clone E05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRQLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P91-98| E02 | codons 1-229 | clone E02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKITKIGPENPYNTPV FAIKKKGSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDVVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDNKHQKEPPFLW >P91-98| E04 | codons 1-229 | clone E04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKITKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPNIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P91-98| E01 | codons 1-229 | clone E01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELGQHLLRWGFTTPDKKHQKEPPFLW >P91-98| E03 | codons 1-229 | clone E03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFITPDKKHQKEHPFLW >P91-98| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |