<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB3-P9 P9-0 U.S. 1998 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  L33I L10I, L19I, N37S, R41K, I62V, L63P, H69Y, I93L  
>P9-0| B04 | codons 1-99 | clone B04
PQITLWQRPIVTIKIGGQIKEALLDTGADDTVIEEMSLPGKWKPKMIGGIGGFIKVRQYD
QVLIEICGYKAIGTVLVGHTPVNIIGRNLLTQLGCTLNF
>P9-0| B07 | codons 1-99 | clone B07
PQITLWQRPIVTIKIGGQIKEALLDTGADDTVIEEMHLPGKWKPKMIGGIGGFIKVRQYD
QVLIEICGYKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>P9-0| B06 | codons 1-99 | clone B06
PQITLWQRPLVTIKIGGQIKEALLDTGADDTVIEEMSLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTKIGCTLNF
>P9-0| B03 | codons 1-99 | clone B03
PQITLWQRPLVTIKIGGQIKEALLDTGADDTVIEEMELPGRWKPKMIGGIGGFIKVRQYD
QVPIEICGYKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>P9-0| B05 | codons 1-99 | clone B05
PQITLWQRPIVTIKIGGQIKEALLDTGADDTVIEEMNLPGKWKPKMIGGIGGFIKVRQYD
QVLIEICGYKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>P9-0| B02 | codons 1-99 | clone B02
PQITLWQRPLVTIKIGGQIKEALLDTGADDTVIEEMSLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>P9-0| codons 1-99
PQITLWQRPIVTIKIGGQIKEALLDTGADDTVIEEMSLPGKWKPKMIGGIGGFIKVRQYD
QVPIEICGYKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V60I, R83K, I178L, Q207A, R211K  
>P9-0| B06 | codons 1-229 | clone B06
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW
>P9-0| B04 | codons 1-229 | clone B04
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSGMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW
>P9-0| B02 | codons 1-229 | clone B02
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW
>P9-0| B03 | codons 1-229 | clone B03
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPGINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW
>P9-0| B07 | codons 1-229 | clone B07
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKEKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGLVT
YQYMDDLYVGSDLEIGQHRTKTEELRAHLLKWGFTTPDKKHQKEPPFLW
>P9-0| B05 | codons 1-229 | clone B05
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTALDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW
>P9-0| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005