Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P9 | P9-0 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33I | L10I, L19I, N37S, R41K, I62V, L63P, H69Y, I93L |
| >P9-0| B04 | codons 1-99 | clone B04 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVIEEMSLPGKWKPKMIGGIGGFIKVRQYD QVLIEICGYKAIGTVLVGHTPVNIIGRNLLTQLGCTLNF >P9-0| B07 | codons 1-99 | clone B07 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVIEEMHLPGKWKPKMIGGIGGFIKVRQYD QVLIEICGYKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P9-0| B06 | codons 1-99 | clone B06 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVIEEMSLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTKIGCTLNF >P9-0| B03 | codons 1-99 | clone B03 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVIEEMELPGRWKPKMIGGIGGFIKVRQYD QVPIEICGYKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P9-0| B05 | codons 1-99 | clone B05 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVIEEMNLPGKWKPKMIGGIGGFIKVRQYD QVLIEICGYKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P9-0| B02 | codons 1-99 | clone B02 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVIEEMSLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P9-0| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVIEEMSLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGYKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V60I, R83K, I178L, Q207A, R211K |
| >P9-0| B06 | codons 1-229 | clone B06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW >P9-0| B04 | codons 1-229 | clone B04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSGMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW >P9-0| B02 | codons 1-229 | clone B02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW >P9-0| B03 | codons 1-229 | clone B03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPGINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW >P9-0| B07 | codons 1-229 | clone B07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKEKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGLVT YQYMDDLYVGSDLEIGQHRTKTEELRAHLLKWGFTTPDKKHQKEPPFLW >P9-0| B05 | codons 1-229 | clone B05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTALDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW >P9-0| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |