Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P87 | P87-72 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 70 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A | L10F | K14R, R41K, L63Q, I64V |
| >P87-72| H04 | codons 1-99 | clone H04 PQITLWQRPFVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P87-72| H05 | codons 1-99 | clone H05 PQITLWQRPFVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P87-72| H01 | codons 1-99 | clone H01 PQITLWQRPLVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P87-72| H08 | codons 1-99 | clone H08 PQITLWQRPFVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVRQYD QIQVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P87-72| H07 | codons 1-99 | clone H07 PQITLWRRPIVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P87-72| H06 | codons 1-99 | clone H06 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVRQYD QIQVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P87-72| codons 1-99 PQITLWQRPFVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | P225H | K122E, D123E, I135M, S162C, T200A, Q207A, R211K |
| >P87-72| H05 | codons 1-229 | clone H05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFTTPDKKHQKEHPFLW >P87-72| H08 | codons 1-229 | clone H08 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPESPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFTTPDKKHQKEHPFLW >P87-72| H04 | codons 1-229 | clone H04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFTTPDKKHQKEHPFLW >P87-72| H07 | codons 1-229 | clone H07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFTTPDKKHQKEHPFLW >P87-72| H01 | codons 1-229 | clone H01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTMPSMNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLRWGFTTPDKKHQKEHPFLW >P87-72| H06 | codons 1-229 | clone H06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYAGSDLEIGQHRAKIEELRAHLLRWGFTTPDKKHQKEHPFLW >P87-72| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFTTPDKKHQKEHPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |