Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P84 | P84-32 | U.S. | 1996 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 30 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V | T12S, L19I, E35D, N37D, L63P, I64V, I93L |
| >P84-32| D06 | codons 1-99 | clone D06 PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF >P84-32| D04 | codons 1-99 | clone D04 PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF >P84-32| D08 | codons 1-99 | clone D08 PQITLWQRPLVSIEIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNL >P84-32| D07 | codons 1-99 | clone D07 PQITPWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAIGTVVVGPTPVDIIGRNLLTQIGCTLNF >P84-32| D05 | codons 1-99 | clone D05 PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF >P84-32| D01 | codons 1-99 | clone D01 PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF >P84-32| D02 | codons 1-99 | clone D02 PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGLKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF >P84-32| D03 | codons 1-99 | clone D03 PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF >P84-32| codons 1-99 PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | K32N, I135T, R211K |
| >P84-32| D07 | codons 1-229 | clone D07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P84-32| D03 | codons 1-229 | clone D03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHLAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQCNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P84-32| D04 | codons 1-229 | clone D04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVRNLYRNGKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P84-32| D06 | codons 1-229 | clone D06 PISPIEAVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTRDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIAI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P84-32| D01 | codons 1-229 | clone D01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPRGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P84-32| D02 | codons 1-229 | clone D02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P84-32| D08 | codons 1-229 | clone D08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P84-32| D05 | codons 1-229 | clone D05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P84-32| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |