<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB3-P72 P72-36 U.S. 1998 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI NA
2 IDV 2
3 EFV+IDV 34

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I L10I, I15V, E35D, K55R, R57K, L63P, H69Q, A71V  
>P72-36| G05 | codons 1-99 | clone G05
PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKMIGGIGGFVRVKQYD
QIPIEICGQKVIGTILVGPTPANIIGRNLLTQIGCTLNF
>P72-36| G06 | codons 1-99 | clone G06
PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKLIGGIGGFVRVKQYD
QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQIGCTLNF
>P72-36| G10 | codons 1-99 | clone G10
PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKLIGGIGGFVRVKQYD
QIPIEICGQKVIGTVLVGPTPADIIGRNLLTQIGCTLNF
>P72-36| G12 | codons 1-99 | clone G12
PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKLIGGIGGFVRVKQYD
QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQIGCTLNF
>P72-36| G09 | codons 1-99 | clone G09
PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKLIGGIGGFVRVKQYD
QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQIGCTLNF
>P72-36| G04 | codons 1-99 | clone G04
PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKLIGGIGGFVRVKQYD
QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQIGCTLNF
>P72-36| codons 1-99
PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKLIGGIGGFVRVKQYD
QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R   K103N   S162C, I178L  
>P72-36| G09 | codons 1-229 | clone G09
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW
>P72-36| G06 | codons 1-229 | clone G06
PISPIETVPVKLKPGMDGPKVKRWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW
>P72-36| G10 | codons 1-229 | clone G10
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW
>P72-36| G12 | codons 1-229 | clone G12
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW
>P72-36| G05 | codons 1-229 | clone G05
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVEFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELGQHLLRWGFTTPDKKHQKEPPFLW
>P72-36| G04 | codons 1-229 | clone G04
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLR
>P72-36| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005