Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P72 | P72-24 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I, F53L | L10I, I15V, E35D, K55R, R57K, L63P, H69Q, A71V |
| >P72-24| E12 | codons 1-99 | clone E12 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKMIGGIGGLIRVKQYD QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P72-24| E06 | codons 1-99 | clone E06 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGLVRVKQYD QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P72-24| E08 | codons 1-99 | clone E08 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKLIGGIGGFVRVKQYD QIPIEICGQKVIGTVLVGPTPANIIGRDLLTQIGCTLNF >P72-24| E05 | codons 1-99 | clone E05 PQITLWQRPIVTIKVGGQLKEALIDTGADGTVLEDMNLPGRWKPKMIGGIGGLVRVKQYD QIPIEICGQKVIGTVLVGPTPANIIGRNLMTQVGCTLNF >P72-24| E04 | codons 1-99 | clone E04 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGLIRVKQYD QIPIEICGQKVIGTVLVGPTPGNIIGRNLLTQIGCTLNF >P72-24| E09 | codons 1-99 | clone E09 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKMIGGIGGFVRVKQYD QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P72-24| codons 1-99 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDMNLPGRWKPKMIGGIGGLVRVKQYD QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | S162C, I178L |
| >P72-24| E04 | codons 1-229 | clone E04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQCNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P72-24| E05 | codons 1-229 | clone E05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVPDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEMGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P72-24| E09 | codons 1-229 | clone E09 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P72-24| E06 | codons 1-229 | clone E06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLW >P72-24| E08 | codons 1-229 | clone E08 PISPIKTVPVKLKPGMDGPKVKRWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRRYTAFTIPSISNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P72-24| E12 | codons 1-229 | clone E12 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P72-24| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |