Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 10546A | 10546A | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NNRTI|NRTI|PI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L33F, L89V | L10I, I13V, L19I, K20R, E35D, M36I, N37E, I62V, L63P, I66F, K70R, A71V, I72T, Q92K |
| >10546A| codons 1-99 PQITLWQRPIVTVKIGGQIREALLDTGADDTVFEDIELPGRWKPKIIGGVGGFVKVRQYD QVPIEFCGHRVTGTVLVGPTPANIIGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V | T215V, K219Q | K101KE, G190A | V35M, E36ED, V60I, R83RK, K122E, E138A, V179I, I202V, R211K, F214FL, D237E, A272P, K277R, I293V, P294PS, E297EK, D324DE, R356K, A360AV, A376S, A400T | G359GRS |
| >10546A| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMDICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVASDLEIGQHRTKVEELRQHLLKWGLVTPDQKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVSLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSV HTNDVKQLTEAVQKISTESIVIWGKTPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Dau, B | Connection domain mutations in treatment-experienced patients in the OPTIMA trial. | JAIDS, 2010 |