Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P66 | P66-48 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 46 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, P39S, R41K, L63A, H69Y |
| >P66-48| B08 | codons 1-99 | clone B08 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLSGKWKPKMIGGIGGFIKVRQYD QIAIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P66-48| B05 | codons 1-99 | clone B05 PQTTLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLSGKWKPKMIGGIGGFIKVRQYD RIAIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P66-48| B02 | codons 1-99 | clone B02 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLSGKWKPKMIGGIGGFIKVRQYD QIAIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P66-48| B01 | codons 1-99 | clone B01 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLSGKWKPKMIGGIGGFIKVRQYD QIAIEIRGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P66-48| B06 | codons 1-99 | clone B06 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLSGK*KPKMIGGIGGFIKVRQYD QIAIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P66-48| B07 | codons 1-99 | clone B07 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLSGKWKPKMIGGIGGFIKVRQYD QIAIEICGYNAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P66-48| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLSGKWKPKMIGGIGGFIKVRQYD QIAIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | Q207E, R211K |
| >P66-48| B08 | codons 1-229 | clone B08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVKICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P66-48| B07 | codons 1-229 | clone B07 PISPIETVPVKLKLGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWRGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P66-48| B06 | codons 1-229 | clone B06 PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P66-48| B02 | codons 1-229 | clone B02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFREPNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P66-48| B01 | codons 1-229 | clone B01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEHPFLW >P66-48| B05 | codons 1-229 | clone B05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFREVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRGHLLKWGFTTPDKKHQKEPPFLW >P66-48| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |