<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 NNRTI|NRTI|PI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T69D, L74V, Y115F, L210W, T215Y   K101E, Y181C, G190S   T7P, K20R, K122E, S162C, R172K, R211K, L228R, E248D, D250E, A272P, P294S, E297K, R356K, G359S, A376S, T386TI, K390R  
>08383A| codons 1-399
PISPIEPVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAFFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPDIVI
CQYMDDLYVSSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT
VQPIVLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVISLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V L24I, N83D, L89V L10I, I13V, K14KN, L19Q, A22V, M36L, N37D, D60E, I62V, L63P, A71V, I72T, T91TS, Q92K  
>08383A| codons 1-99
PQITLWQRPIVTVNIGGQQKEVLIDTGADDTVLEELDLPGRWKPKIIGGIGGFVKVRQYE
QVPIEICGHKVTGTVLVGPTPVDVIGRNVLSKIGCTLNF

References
Author Title Citation
Dau, B Connection domain mutations in treatment-experienced patients in the OPTIMA trial. JAIDS, 2010