Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P6 | P6-2 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, E35D, N37D, I62V, L63P, A71T, I72E, V77I, I93L |
| >P6-2| E02 | codons 1-99 | clone E02 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| E03 | codons 1-99 | clone E03 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAEGTVLVGPTPVNIIGRNLLTQLGCTLNF >P6-2| 062E09 | codons 1-99 | clone 062E09 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAEGTVLVGPTPVNIIGRNLLTQLGCTLNF >P6-2| 062E08 | codons 1-99 | clone 062E08 PQITLWPRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| 068E05 | codons 1-99 | clone 068E05 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAEGTVLVGPTPVNIIGRNLLTQLGCTLNF >P6-2| 068E08 | codons 1-99 | clone 068E08 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| 062E07 | codons 1-99 | clone 062E07 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| 062E05 | codons 1-99 | clone 062E05 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| E10 | codons 1-99 | clone E10 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| E01 | codons 1-99 | clone E01 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMDLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| 068E09 | codons 1-99 | clone 068E09 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| E04 | codons 1-99 | clone E04 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMELPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| E06 | codons 1-99 | clone E06 PQITLWQRPLVTIRIGGQIKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTKGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| E07 | codons 1-99 | clone E07 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| E11 | codons 1-99 | clone E11 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMDLSGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF >P6-2| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTEGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V90I, V179I, R211K |
| >P6-2| E02 | codons 1-229 | clone E02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| E10 | codons 1-229 | clone E10 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKIPKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLSKWGFTTPGKKHQKEPPFLW >P6-2| E11 | codons 1-229 | clone E11 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKEKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKTLEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| 068E08 | codons 1-229 | clone 068E08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILGPFRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGLTTPDKKHQKEPPLLW >P6-2| 068E05 | codons 1-229 | clone 068E05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPYRKQNPDIII YQYMDDLCVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| 062E07 | codons 1-229 | clone 062E07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIGELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| 062E09 | codons 1-229 | clone 062E09 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPYRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| E03 | codons 1-229 | clone E03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| 062E05 | codons 1-229 | clone 062E05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| 068E09 | codons 1-229 | clone 068E09 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPYRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| E04 | codons 1-229 | clone E04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWKKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| E01 | codons 1-229 | clone E01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| 062E08 | codons 1-229 | clone 062E08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL GKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLLKWGLTTPDKKHQKEPPFLW >P6-2| E06 | codons 1-229 | clone E06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL DKDSRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSNLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| E07 | codons 1-229 | clone E07 PISPIETVPVKLKPGMDGPKVKQWPLTEGKIKALVEICTEMEKEGKISKIGPENPYNTPV LAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSIDNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPYRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P6-2| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |