Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | NNRTI|NRTI|PI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | Q58QE | L10V, I15V, K20R, M36MI, K55R, R57K, D60DE, L63P, A71V, I93L |
| >05505A| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVRVKEYE QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | D67DG, K219N | K103N, Y181C, G190A | K20R, K43QR, V60I, S68G, K101Q, K122E, I142V, I178M, R211K, E224ED, L228R, V245T, I293V, M357T, R358RK, T369TA, K390R |
| >05505A| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEREGKISKIGPENPYNTPI FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI CQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDNKHQKDPPFRWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLAEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Dau, B | Connection domain mutations in treatment-experienced patients in the OPTIMA trial. | JAIDS, 2010 |