Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P57 | P57-87 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV | 2 |
| 3 | EFV+IDV | 87 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | K20R, N37D, L63S, A71V, T74S, I93L |
| >P57-87| A07 | codons 1-99 | clone A07 PQITLWQRPLVTIKIGGQLREALLGTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF >P57-87| A03 | codons 1-99 | clone A03 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF >P57-87| A01 | codons 1-99 | clone A01 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF >P57-87| A05 | codons 1-99 | clone A05 PQITLWQRPHVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGSVLIGPTPASIIGRNLLTQLGCTLNF >P57-87| A06 | codons 1-99 | clone A06 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF >P57-87| A08 | codons 1-99 | clone A08 PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF >P57-87| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103N | T200A, Q207H, R211K |
| >P57-87| A03 | codons 1-229 | clone A03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-87| A08 | codons 1-229 | clone A08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-87| A07 | codons 1-229 | clone A07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNTRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-87| A01 | codons 1-229 | clone A01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIRKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-87| A05 | codons 1-229 | clone A05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-87| A06 | codons 1-229 | clone A06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-87| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |