Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P57 | P57-12 | U.S. | 1996 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV | 2 |
| 3 | EFV+IDV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K20R, N37D, L63S, A71V, I93L |
| >P57-12| D02 | codons 1-99 | clone D02 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P57-12| D04 | codons 1-99 | clone D04 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRRKPKMIGGIGGFIKVRQYD QISIEICGHKVIGTVLVGPTPVNMIGRNLLTQLGCTLNF >P57-12| D06 | codons 1-99 | clone D06 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P57-12| D03 | codons 1-99 | clone D03 PQITLWQRPLVTIKIGEQLREALLDTGADDTVLEEMDSPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P57-12| D07 | codons 1-99 | clone D07 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P57-12| D05 | codons 1-99 | clone D05 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P57-12| D08 | codons 1-99 | clone D08 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPEMVGGIGGFIKVRQYD QISIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P57-12| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QISIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | T200A, Q207H, R211K |
| >P57-12| D06 | codons 1-229 | clone D06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLHVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-12| D02 | codons 1-229 | clone D02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-12| D04 | codons 1-229 | clone D04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-12| D08 | codons 1-229 | clone D08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-12| D07 | codons 1-229 | clone D07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW >P57-12| D03 | codons 1-229 | clone D03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLTKNKSVTVLDVGDAYFSVPL DKDFRRYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYMDDLHVGSDLEIGQHRAKIEELRHHLLKWGFTKPDKKHQKEPPFLW >P57-12| D05 | codons 1-229 | clone D05 PISPIETVPVELKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKIL*PFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEKLRHHLLKWGFTTPGKKHQKEPPFLW >P57-12| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRHHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |