Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P50 | P50-96 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV | 2 |
| 3 | EFV+IDV | 96 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10I, I13V, K20I, M36I, D60E, Q61E, I62M, L63P, I64M, A71V, I72T, I93L |
| >P50-96| C07 | codons 1-99 | clone C07 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE EVPMEICGHKVTGTVLVGPTPVNIIGRNLMTQLGCTLNF >P50-96| C06 | codons 1-99 | clone C06 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYE EMPMEICGHKVTGTVLVGPTPVNIIGRNLMTQLGCTLNF >P50-96| C11 | codons 1-99 | clone C11 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYE EMPMEICGHKVTGTVLVGPTPVNIIGRNLMTQLGCALNF >P50-96| C04 | codons 1-99 | clone C04 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE EMPMEICGHKVTGTVLVGPTPVNIIGRNLMTQLGCTLNF >P50-96| C10 | codons 1-99 | clone C10 PQITLWQRPIVTVKIGGQLIEAPLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYE EMPMEICGHKVTGTVLVGPTPVNIIGRNLMTQLGCTLNF >P50-96| C08 | codons 1-99 | clone C08 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFIKVRQYE EMPMEICGHKVTGTVLVGPTPVNIIGRNLMTQLGCTLNF >P50-96| codons 1-99 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYE EMPMEICGHKVTGTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | K103N | V35T, R83K, R211K |
| >P50-96| C07 | codons 1-229 | clone C07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELRQHLLKWGFYTPDKKHQKEPPFLW >P50-96| C10 | codons 1-229 | clone C10 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSGMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >P50-96| C04 | codons 1-229 | clone C04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >P50-96| C06 | codons 1-229 | clone C06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKTGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEAQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSISNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >P50-96| C08 | codons 1-229 | clone C08 PISPIETVSVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW >P50-96| C11 | codons 1-229 | clone C11 LISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIGELRQHLLKWGFYTPDKKHQKEPPFLW >P50-96| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |