Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P47 | P47-71 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 69 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | L10I, I13V, L63P, A71I |
| >P47-71| C03 | codons 1-99 | clone C03 PQITLWQRPIVTVKIGGQLKEALLDTGADDTILEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQIGCTLNF >P47-71| C04 | codons 1-99 | clone C04 PQITLWQRPIVTVKIGGQLKEALLDTGADDTILEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQIGCTLNF >P47-71| C05 | codons 1-99 | clone C05 PQITLWQRPIVTVKIGGQLKEALLDTGADDTILEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQIGCTLNF >P47-71| C06 | codons 1-99 | clone C06 PQITLWQRPIVTVKIGGQLTEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQIGCTLNF >P47-71| C07 | codons 1-99 | clone C07 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVLSTVLVGPTPVNIIGRNLMTQIGCTLNF >P47-71| C01 | codons 1-99 | clone C01 PQITLWQRPIVTVKIGGQLKEALLDTGADDTILEEMNLPGRWKPKIIGGIGGFIKVRRYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQIGCTLNF >P47-71| C02 | codons 1-99 | clone C02 PQITLWQRPIVTVKIGGQLKEALLDTGADDTILEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVLSTVLVGPTPVNIIGRNLMTQIGCTLNF >P47-71| C08 | codons 1-99 | clone C08 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQCD QIPIEICGHKVLSTVLVGPTPVNIIGRNLMTQIGCTLNF >P47-71| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTILEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | K103N | P225H | K122E, D123N, I142V, T200A |
| >P47-71| C07 | codons 1-229 | clone C07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHGAKIEELRQHLLRWGFTTPDKKHRKEHPFLW >P47-71| C04 | codons 1-229 | clone C04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P47-71| C08 | codons 1-229 | clone C08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P47-71| C05 | codons 1-229 | clone C05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSIDNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P47-71| C06 | codons 1-229 | clone C06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDSRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQRWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P47-71| C03 | codons 1-229 | clone C03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNGTPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P47-71| C01 | codons 1-229 | clone C01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P47-71| C02 | codons 1-229 | clone C02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P47-71| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEHPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |