Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P44 | P44-1 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV | 2 |
| 3 | EFV+IDV | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V56A, L63T, I64M, I72V |
| >P44-1| E04 | codons 1-99 | clone E04 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKARQYD QITMEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P44-1| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKARQYD QITMEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| A98S, R206G, Q207E, R211K, K223R |
| >P44-1| E04 | codons 1-229 | clone E04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELGEHLLKWGFTTPDKKHQREPPFLW >P44-1| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELGEHLLKWGFTTPDKKHQREPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |