<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB3-P39 P39-25 U.S. 1996 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI NA
2 IDV 2
3 EFV+IDV 23

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82T   L10I, N37D, I62V, L63H, V77I, I93L  
>P39-25| H08 | codons 1-99 | clone H08
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLVGPTPTNIIGRNLLTQLGCTLNF
>P39-25| H04 | codons 1-99 | clone H04
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKLIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF
>P39-25| H07 | codons 1-99 | clone H07
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-25| H01 | codons 1-99 | clone H01
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-25| H03 | codons 1-99 | clone H03
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-25| H10 | codons 1-99 | clone H10
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-25| H09 | codons 1-99 | clone H09
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-25| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215Y       T27S, K43N, I142V, Q174K, Q207N, R211K  
>P39-25| H03 | codons 1-229 | clone H03
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-25| H09 | codons 1-229 | clone H09
PISPIETVPVKLEPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWGKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-25| H04 | codons 1-229 | clone H04
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRNHLWKWGFYTPDKKHQKEPPLLW
>P39-25| H07 | codons 1-229 | clone H07
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKERKISKIGPENPYNTPV
FAIKKKDSTKWGKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYDVLPQGWKGSPAIFQSSVTKILEPFRKKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-25| H08 | codons 1-229 | clone H08
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVKICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRNHLWKWGFYTPDKKHQKEPPFLW
>P39-25| H10 | codons 1-229 | clone H10
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNAPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-25| H01 | codons 1-229 | clone H01
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNGTPGVRYQYNVLPQGWKGSPAIFQSSTTKILEPFRKKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-25| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005