Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P39 | P39-25 | U.S. | 1996 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 23 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82T | L10I, N37D, I62V, L63H, V77I, I93L |
| >P39-25| H08 | codons 1-99 | clone H08 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLVGPTPTNIIGRNLLTQLGCTLNF >P39-25| H04 | codons 1-99 | clone H04 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKLIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P39-25| H07 | codons 1-99 | clone H07 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-25| H01 | codons 1-99 | clone H01 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-25| H03 | codons 1-99 | clone H03 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-25| H10 | codons 1-99 | clone H10 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-25| H09 | codons 1-99 | clone H09 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-25| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | T27S, K43N, I142V, Q174K, Q207N, R211K |
| >P39-25| H03 | codons 1-229 | clone H03 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-25| H09 | codons 1-229 | clone H09 PISPIETVPVKLEPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWGKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-25| H04 | codons 1-229 | clone H04 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRNHLWKWGFYTPDKKHQKEPPLLW >P39-25| H07 | codons 1-229 | clone H07 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKERKISKIGPENPYNTPV FAIKKKDSTKWGKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYDVLPQGWKGSPAIFQSSVTKILEPFRKKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-25| H08 | codons 1-229 | clone H08 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVKICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRNHLWKWGFYTPDKKHQKEPPFLW >P39-25| H10 | codons 1-229 | clone H10 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNAPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-25| H01 | codons 1-229 | clone H01 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNGTPGVRYQYNVLPQGWKGSPAIFQSSTTKILEPFRKKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-25| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |