Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P39 | P39-60 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 58 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82T | L10I, N37D, L63P, V77I, I93L |
| >P39-60| C08 | codons 1-99 | clone C08 PQNTLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-60| C03 | codons 1-99 | clone C03 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGTGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-60| C05 | codons 1-99 | clone C05 PQITLW*RPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGVGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-60| C01 | codons 1-99 | clone C01 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFNKVRQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-60| C02 | codons 1-99 | clone C02 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-60| C06 | codons 1-99 | clone C06 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRLYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-60| C04 | codons 1-99 | clone C04 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-60| C09 | codons 1-99 | clone C09 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-60| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | G190S | T27S, I142V, Q207N, R211K |
| >P39-60| C06 | codons 1-229 | clone C06 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-60| C09 | codons 1-229 | clone C09 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-60| C05 | codons 1-229 | clone C05 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-60| C02 | codons 1-229 | clone C02 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHGTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-60| C08 | codons 1-229 | clone C08 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPA FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFREYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLEWGFYTPDKKHQKEPPFLW >P39-60| C04 | codons 1-229 | clone C04 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYISSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-60| C01 | codons 1-229 | clone C01 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-60| C03 | codons 1-229 | clone C03 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGGAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGPPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-60| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |