<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB3-P39 P39-44 U.S. 1997 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI NA
2 IDV 2
3 EFV+IDV 42

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82T   L10I, N37D, I62V, L63H, V77I, I93L  
>P39-44| F05 | codons 1-99 | clone F05
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-44| F09 | codons 1-99 | clone F09
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMLGGIGGFIKVRQYD
QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-44| F03 | codons 1-99 | clone F03
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-44| F08 | codons 1-99 | clone F08
PQITLWQRPIVTIKIGGQLKEALLDTGAGDTVLEEMDLPGRWKPKMIGGTGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-44| F02 | codons 1-99 | clone F02
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGLIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-44| F07 | codons 1-99 | clone F07
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-44| F01 | codons 1-99 | clone F01
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGIVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-44| F04 | codons 1-99 | clone F04
PQITLWQRPIATIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLAQLGCTLNF
>P39-44| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215Y   G190S   T27S, K43N, I142V, Q207N, R211K  
>P39-44| F07 | codons 1-229 | clone F07
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIRALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-44| F09 | codons 1-229 | clone F09
PISPIETVPVKLKPGMDGPKAKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQSGIPPPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRNHLLEWGFYTPDKKHQKEPPFLW
>P39-44| F03 | codons 1-229 | clone F03
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-44| F05 | codons 1-229 | clone F05
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIKELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-44| F01 | codons 1-229 | clone F01
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-44| F02 | codons 1-229 | clone F02
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-44| F04 | codons 1-229 | clone F04
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPHNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRY*YNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-44| F08 | codons 1-229 | clone F08
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPRGWKGSPAISQSSMTKILEPFRKKNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELGNHLLKWGFYTPDKKHQKEPPFLW
>P39-44| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005