<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB3-P39 P39-84 U.S. 1998 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI NA
2 IDV 2
3 EFV+IDV 82

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82T   L10I, N37D, I62V, L63H, V77I, I93L  
>P39-84| H06 | codons 1-99 | clone H06
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIVGRNLLTQLGCTLNF
>P39-84| H01 | codons 1-99 | clone H01
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKLIGGIGGFIRVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-84| H05 | codons 1-99 | clone H05
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTALIGPTPTNIIGRNLLTQLGCTLNF
>P39-84| H02 | codons 1-99 | clone H02
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P39-84| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215Y   G190S   T27S, K43N, K101Q, I142V, Q207N, R211K  
>P39-84| H01 | codons 1-229 | clone H01
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPGINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFRW
>P39-84| H06 | codons 1-229 | clone H06
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-84| H05 | codons 1-229 | clone H05
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-84| H02 | codons 1-229 | clone H02
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI
YQYMDDLYVSSDLEIGHHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW
>P39-84| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005