Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P37 | P37-84 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 82 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | L24I | L10V, E35D, M36I, I62V, L63P, H69Q, V77I |
| >P37-84| G01 | codons 1-99 | clone G01 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLAQLGCTLNF >P37-84| G07 | codons 1-99 | clone G07 PQITLWQRPVVTIKVGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-84| G06 | codons 1-99 | clone G06 PQITLWQRPVVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKTIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-84| G05 | codons 1-99 | clone G05 PQITLWQRPVVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKTIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-84| G04 | codons 1-99 | clone G04 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKTIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-84| G03 | codons 1-99 | clone G03 PQITLWQRPVVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAMGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-84| G08 | codons 1-99 | clone G08 PQITLWQRPVVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVSIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-84| G02 | codons 1-99 | clone G02 PQITLWQRPVVTIKVGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >P37-84| codons 1-99 PQITLWQRPVVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | A98S, I135V, T200A |
| >P37-84| G07 | codons 1-229 | clone G07 PISPIETVPVKLEPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI HQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-84| G01 | codons 1-229 | clone G01 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKRQKEPPFLW >P37-84| G06 | codons 1-229 | clone G06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVIVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-84| G05 | codons 1-229 | clone G05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDSRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIVELRQHLLRWGFTTPDKKHQKEPPFLW >P37-84| G04 | codons 1-229 | clone G04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRRHLLRWGFTTPDKKHQKEPPFLW >P37-84| G02 | codons 1-229 | clone G02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKRKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-84| G08 | codons 1-229 | clone G08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-84| G03 | codons 1-229 | clone G03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLEDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-84| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |