Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P37 | P37-60 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 58 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | L24I | E35D, M36I, I62V, L63P, H69Q, V77I |
| >P37-60| 111E05 | codons 1-99 | clone 111E05 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-60| E01 | codons 1-99 | clone E01 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPRIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-60| E02 | codons 1-99 | clone E02 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-60| E08 | codons 1-99 | clone E08 PQIALWQRPLATIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-60| E07 | codons 1-99 | clone E07 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFTKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-60| E04 | codons 1-99 | clone E04 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-60| E06 | codons 1-99 | clone E06 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P37-60| codons 1-99 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | A98S, I135V, T200A |
| >P37-60| E04 | codons 1-229 | clone E04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKRHQKEPPFLW >P37-60| 111E05 | codons 1-229 | clone 111E05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-60| E02 | codons 1-229 | clone E02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNAPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-60| E01 | codons 1-229 | clone E01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-60| E07 | codons 1-229 | clone E07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAHFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-60| E06 | codons 1-229 | clone E06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-60| E08 | codons 1-229 | clone E08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DRDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P37-60| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |