Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P26 | P26-16 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV | 2 |
| 3 | EFV+IDV | 16 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, V82A | I15V, E35D, N37D, L63P, H69Q, A71I |
| >P26-16| G02 | codons 1-99 | clone G02 PQITLWQRPLVTIKVGGQLKEALLDTGADDTILEDMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGQKIIGTVLVGPTPANIIGRNLLTQIGCTLNF >P26-16| G04 | codons 1-99 | clone G04 PQITLWQRPLVTIKVGGQLKEALIDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P26-16| G06 | codons 1-99 | clone G06 PQITLWQRPLVTIKVGGQLKEALLDTGADDTILEDMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGQKIIGTVLVGPTPANIIGRNLLTQIGCTLNF >P26-16| G01 | codons 1-99 | clone G01 PQITLWQRPLVTIKVGGQLKEALLDTGADDTILEDMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGQKIIGTVLVGPTPANIIGRNLLTQIGCTLNF >P26-16| G08 | codons 1-99 | clone G08 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P26-16| G05 | codons 1-99 | clone G05 PQITLWQRPLVTIKVGGQLKEALLDTGADDTILEDMGLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGQKIIGTVLVGPTPANIIGRNLLTQIGCTLNF >P26-16| G03 | codons 1-99 | clone G03 PQITLWQRPLVTIKVGGQLKEALIDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPANIIGRNLLTQVGCTLNF >P26-16| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTILEDMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGQKIIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | K103N, Y188L | D121Y, K122E, E138A, S162C, T200A, E224D |
| >P26-16| G03 | codons 1-229 | clone G03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKDPPFLW >P26-16| G05 | codons 1-229 | clone G05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPRPAGIKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRRQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKRGFYTPDKKHQKDPPFLW >P26-16| G01 | codons 1-229 | clone G01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P26-16| G08 | codons 1-229 | clone G08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKKTQDFWEVRLGIPHPAGLKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKDPPFLW >P26-16| G04 | codons 1-229 | clone G04 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVPDVGDAYFSVPL YEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P26-16| G06 | codons 1-229 | clone G06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKKPPFRW >P26-16| G02 | codons 1-229 | clone G02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRIQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIRQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P26-16| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKDPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |