Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P25 | P25-0 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33V, R41K, L63Q, I64V, E65D |
| >P25-0| B07c | codons 1-99 | clone B07c PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P25-0| B05c | codons 1-99 | clone B05c PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P25-0| B04a | codons 1-99 | clone B04a PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P25-0| A06g | codons 1-99 | clone A06g PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P25-0| B04b | codons 1-99 | clone B04b PQIALWQRPLVTVKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P25-0| B03c | codons 1-99 | clone B03c PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P25-0| B01a | codons 1-99 | clone B01a PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAIGTVLVGLTPVNIIGRNLLTQIGCTLNF >P25-0| B06b | codons 1-99 | clone B06b PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P25-0| B01 | codons 1-99 | clone B01 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P25-0| B08b | codons 1-99 | clone B08b PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P25-0| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVRQYD QIQVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| A62V, V75I | K20R, R83K, K103R, G196E, T200A, R211K |
| >P25-0| B05c | codons 1-229 | clone B05c PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPL FVIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P25-0| B04a | codons 1-229 | clone B04a PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSIKWRKLIDFRELNKKTQDSWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DRDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIEQHRAKIEDLRQHLLKWGFTTPDKKHQKEPPFLW >P25-0| B08b | codons 1-229 | clone B08b PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKKTQDLWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIEQHRAKIEDLRQHLLRWGFTTPDKKHQKEPPFLW >P25-0| B07c | codons 1-229 | clone B07c PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P25-0| B03b | codons 1-229 | clone B03b PISPIETVPVKLKPGVDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYHVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P25-0| B01 | codons 1-229 | clone B01 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYMDDLYVGSDLEIEQHRAKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P25-0| B06b | codons 1-229 | clone B06b PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRAKIENLRQHLLKWGFTTPDKKHQKEPPFLW >P25-0| A06g | codons 1-229 | clone A06g PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIEQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P25-0| B04b | codons 1-229 | clone B04b PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKVSKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDVVI YQYMDDLYVESDLEIEQHRAKIEDLRQHLLKWGFTTPDKKHQKEPPFLW >P25-0| B03c | codons 1-229 | clone B03c PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVESDLEIEQHRAKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P25-0| B01a | codons 1-229 | clone B01a PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVLKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVESDLEIEQHRTKIEELRQRLLRWGFTTPDKKHQKEPPFLW >P25-0| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRAKIEELRQHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |