Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P1 | P1-16 | U.S. | 1996 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV+IDV | 16 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G73S | L10I, E35D, M36I, I62V, L63P, A71V, V77I, I93L |
| >P1-16| D05 | codons 1-99 | clone D05 PQITLWQRPIVTIKIGGHLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLLTQLGCTLNF >P1-16| D07 | codons 1-99 | clone D07 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLLTQLGCTLNF >P1-16| D03 | codons 1-99 | clone D03 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLLTQLGCTLNF >P1-16| D02 | codons 1-99 | clone D02 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTLVNIIGRNLLTQLGCTLNF >P1-16| D08 | codons 1-99 | clone D08 PQITLWQRPIATIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMVGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLLTQLGCTLNF >P1-16| D04 | codons 1-99 | clone D04 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLLTQLGCTLNF >P1-16| D01 | codons 1-99 | clone D01 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLLTQLGCTLNF >P1-16| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K70Q | K103N | E40F, K43E, V118I, G196E, T200I, Q207E, R211K |
| >P1-16| D01 | codons 1-229 | clone D01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRIKIEELREHLWKWGFYTPDKKHQKEPPFLW >P1-16| D08 | codons 1-229 | clone D08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRIKIEELREHLWKWGFYTPDKKHQKEPPFLW >P1-16| D05 | codons 1-229 | clone D05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRIKIEELREHLWKWGFYTPDKKHQKEPPFLW >P1-16| D04 | codons 1-229 | clone D04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRIKIEELREHLWKWGFYTPDKKHQKEPPFLW >P1-16| D02 | codons 1-229 | clone D02 PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRIKIEELREHLWKWGFYTPDKKHQKEPPFLW >P1-16| D03 | codons 1-229 | clone D03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRIKIEELREHLWKWGFYTPDKKHQKEPPFLW >P1-16| D07 | codons 1-229 | clone D07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRIKIEELRGHLWKWGFYTPDKKHQKEPPFLW >P1-16| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRIKIEELREHLWKWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |