Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P1 | P1-56 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV+IDV | 56 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | L10I, E35D, M36I, I62V, L63P, A71V, V77I, I93L |
| >P1-56| H09 | codons 1-99 | clone H09 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF >P1-56| H06 | codons 1-99 | clone H06 PQITLWQRPIVTIKIGGLLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF >P1-56| H08 | codons 1-99 | clone H08 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGTGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF >P1-56| H10 | codons 1-99 | clone H10 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF >P1-56| H05 | codons 1-99 | clone H05 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF >P1-56| H12 | codons 1-99 | clone H12 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF >P1-56| H02 | codons 1-99 | clone H02 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINSPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNTIGRNLMTQLGCTLNF >P1-56| H11 | codons 1-99 | clone H11 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF >P1-56| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184I, L210W | K70A, T215D | K103N | E40F, K43E, V118I, G196E, K201I, H208F, R211K |
| >P1-56| H08 | codons 1-229 | clone H08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTAWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIEQHRTIIKELRQFLWKWGFDTPDKKHQKEPPFLW >P1-56| H06 | codons 1-229 | clone H06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIEQHRTIIEELRQFLWKWGFDTPDKKHQKEPPFLW >P1-56| H02 | codons 1-229 | clone H02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTAWRRLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIEQHRAIIEELRQFLWKWGFDTPDKKHQKEPPFLW >P1-56| H09 | codons 1-229 | clone H09 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTAWRRLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIEQHRTIIEELRQFLWKWGFDTPDKKHQKEPPFLW >P1-56| H10 | codons 1-229 | clone H10 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTAWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIEQHRTIIEELRQFLWKWGFDTPDKKHQKEPPFLW >P1-56| H11 | codons 1-229 | clone H11 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIEQHRTIIEELRQFLWK*GFDTPDKKHQKEPPFLW >P1-56| H12 | codons 1-229 | clone H12 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTAWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIEQHRAIIEELRQFLWKWGFDTPDKKHQKEPPFLW >P1-56| H05 | codons 1-229 | clone H05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTAWRKLMDFRELNKRTQDFWEVQLGIPRPAGLKRNKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIEQHRAIIEELRQFLWKWGFDTPDKKHQKEPPFLW >P1-56| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTAWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIEQHRTIIEELRQFLWKWGFDTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |