Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SK226 | SK226 | South Africa | 2008 | HIV1 | CRF49_cpx | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, M50I, F100Y, L101I, T112V, S119T, T124A, T125A, K136Q, M154T, K188R, V201I, T206S, T218I, L234I, I251L, A265V, D278A | S283G |
| >SK226| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGTN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESTNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRRGGIGGYSAGERIIDIIASDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVLQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, M36I, R41K, H69K, L89M, I93L |
| >SK226| codons 1-99 PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, V60I, D123G, K173T, D177E, T200A, Q207E, V245K, A272P, T286V, E291D, V292I, I293V, I329V, Q334H, G335D, R356K, M357R, G359T, A360T, T377M, K390R, A400T, E404D, I434L, V435E, A437V, L452I, S468T, L469I, D471E, T477S, H483Q, L491S, V496I, S519N, Q524E, A534S, A554S |
| >SK226| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGVKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTT HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPLEGVETFYVDGAANRETKIGKAGYVTDRGRQKVVTITETTNQKSELQ AIQLALQDSGSEVNIITDSQYALGIIQAQPDKSESELVNQIIEELIKKEKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Matthews, PC | Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. | J Virol, 2008 |