<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  V54I I5V, S17N, D25E, V31I, M50I, I60V, I72V, I84M, F100Y, L101I, T112I, T124A, T125A, K136Q, V201I, T206S, T218I, K219Q, L234I, S255G, R269K, D278A S283G
>SK213| codons 1-288
FLDGVDKAQEEHEKYHNNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQIDCSPGV
WQLDCTHLEGKVILVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKIIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQIIQIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNGDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, N37S, R41K, L63P, H69K, V77I, I93L  
>SK213| codons 1-99
PQITLWQRPLVSIKVGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGKKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39E, S48T, K122E, D123S, I135T, S162C, K173A, Q174K, D177E, T200A, Q207A, R211K, F214L, V245Q, A272P, V276I, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, K366R, T377L, T386S, K390R, A400T, E404D, V435A, N447H, L452T, V458I, R461K, V466I, T470N, D471E, T477A, H483Q, S519N, Q524L, K527N, K530R, V531I, A534S, V548I, A554S, I556V, V559A  
>SK213| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVRQLTEAVQKIALESIVIWGKSPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAAHRETKTGKAGYITDKGRQKIVSLNETTNQKAELQ
AIQLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIELLINKERIYLSWVPAHK
GIGGNEQIDKLVSSGVRKAL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008