<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  T97A E11D, K14R, S24N, D25E, V31I, M50I, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, T218I, L234I, D278A V281A, S283G
>SK212| codons 1-288
FLDGIDKAQEDHERYHSNWRAMANEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQEAAYFILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCAAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54T   T12S, I15V, G17D, L19T, K20M, M36I, R41K, L63I, H69K, L89M, I93L  
>SK212| codons 1-99
PQITLWQRPLVSIKVGDQTMEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFTKVRQYD
QIIIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, V60I, K122E, D123G, S162C, K173A, Q174K, D177E, I178L, T200A, I202M, Q207E, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377Q, K390R, A400T, E404D, V435A, E449D, L452I, R461K, V466I, S468T, D471E, T477A, H483Q, V496I, S519N, K527N, K530R, V531I, A534S, A554S, I556V, K558R N147S
>SK212| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYSVLPQGWKGSPAIFQCSMTKILEPFRAKNPELVI
YQYMDDLYVGSDLEIGQHRAKMEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGVKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIAQESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRDTKIGKAGYVTDKGRQKIVTLTETTNQKAELQ
AIQLALQDSGLEVNIITDSQYALGIIQAQPDKSESELVNQIIEQLINKERIYLSWVPAHK
GIGGNEQVDKLVSSGVRRVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008