Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB5-P167 | P167-50 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+EFV | 16 |
| 2 | 3TC+AZT+EFV+PI | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | F53L | E35D, M36I, R57K, L63P, V77I, I93L, C95F |
| >P167-50| E04 | codons 1-99 | clone E04 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF >P167-50| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF >P167-50| E07 | codons 1-99 | clone E07 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF >P167-50| E06 | codons 1-99 | clone E06 PQIALWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF >P167-50| E05 | codons 1-99 | clone E05 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF >P167-50| E02 | codons 1-99 | clone E02 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYE QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | V21I, I135M, S162C, Q207E, R211A |
| >P167-50| codons 1-229 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEPPFLW >P167-50| E07 | codons 1-229 | clone E07 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFREYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEPPFLW >P167-50| E02 | codons 1-229 | clone E02 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEHPFLW >P167-50| E04 | codons 1-229 | clone E04 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL DKNFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQDPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEPPFLW >P167-50| E05 | codons 1-229 | clone E05 PISPIETVPVKLRPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEPPFLW >P167-50| E06 | codons 1-229 | clone E06 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTK*KKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDL*VGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHEKESPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |