<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB5-P167 P167-50 U.S. 1998 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 3TC+AZT+EFV 16
2 3TC+AZT+EFV+PI 34

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I F53L E35D, M36I, R57K, L63P, V77I, I93L, C95F  
>P167-50| E04 | codons 1-99 | clone E04
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD
QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF
>P167-50| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD
QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF
>P167-50| E07 | codons 1-99 | clone E07
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD
QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF
>P167-50| E06 | codons 1-99 | clone E06
PQIALWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD
QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF
>P167-50| E05 | codons 1-99 | clone E05
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD
QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGFTLNF
>P167-50| E02 | codons 1-99 | clone E02
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYE
QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    K103N   V21I, I135M, S162C, Q207E, R211A  
>P167-50| codons 1-229
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEPPFLW
>P167-50| E07 | codons 1-229 | clone E07
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFREYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEPPFLW
>P167-50| E02 | codons 1-229 | clone E02
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEHPFLW
>P167-50| E04 | codons 1-229 | clone E04
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL
DKNFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQDPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEPPFLW
>P167-50| E05 | codons 1-229 | clone E05
PISPIETVPVKLRPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHQKEPPFLW
>P167-50| E06 | codons 1-229 | clone E06
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTK*KKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDL*VGSDLEIGQHRTKIEELREHLLAWGFTTPDKKHEKESPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005