<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19V, K20R, E35D, M36I, R41K, L63I, H69K, L89M, I93L  
>SK147| codons 1-99
PQITLWQRPLVSIKVGGQVREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIIIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39D, S48T, V60I, K122E, D123G, S162N, K166R, K173A, Q174K, D177E, T200A, Q207A, V245Q, A272P, K277S, T286A, E291D, V292I, I293V, R307G, D324E, Q334R, G335D, R356K, M357R, G359T, T377L, T386I, K390R, A400T, E404D, V435T, V466I, S468H, D471E, H483Q, L491S, E492A, S519N, A534S, A554K N81S
>SK147| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELSKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVSQLCKLLRGAKALTDIVPLTEEAE
LELAENGEILKEPVHGVYYDPSKELIAEIQKQGRDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIALESIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPITGAETFYVDGAANRETKLGKAGYVTDRGRQKIVHLTETTNQKTELQ
AIQLALQDSGSAVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK
GIGGNEQVDKLVSKGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E10V, S17N, D25E, V31I, L45Q, M50I, I72V, F100Y, L101I, T112V, T125A, K136Q, V201I, T218I, L234I, D256E, A265V, D278A S283G
>SK147| codons 1-288
FLDGIDKAQVEHEKYHNNWRAMASEFNLPPIVAKEIVASCDKCQQKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSEIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008