<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S17N, V31I, M50I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, T206S, K211Q, K215R, T218I, I220V, L234I, A265V, R269K, D278A S283G
>SK144| codons 1-288
FLDGIDKAQEEHEKYHNNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIASDIQTQELQRQIIKVQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    W6R, T12S, L19I, M36I, R41K, L63P, I64L, H69K, L89M, I93L  
>SK144| codons 1-99
PQITLRQRPLVSIKIGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIPLEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39D, S48T, K122E, D123S, I135T, K173A, D177E, I195L, G196M, T200A, Q207E, R211K, K238R, V241I, V245Q, D250E, A272P, K275Q, T286A, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, R358G, G359S, K366R, T369A, E370A, A371V, A376T, K390R, A400T, E404D, V435M, A437V, L452T, S468T, D471E, I482V, H483Q, L491S, A502V, S519N, K530R, A534S, A554S  
>SK144| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI
YQYMDDLYVGSDLELMQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDRWT
IQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIQVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMGSA
HTNDVRQLAAVVQKITTESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIMGVETFYVDGAANRETKTGKAGYVTDRGRQKVVTLTETTNQKTELQ
AVQLALQDSGSEVNIVTDSQYVLGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008