Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P153 | P153-8 | U.S. | 1996 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | Y188L, G190E | E6D, V60I, S68G, T69N, D123E, I135T, E194K, R199K, T200A, Q207A | P97L, Q151R |
| >P153-8| H02 | codons 1-229 | clone H02 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDGNKWRKLVDFRELNKRTQDFWEVQLGIPHLAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPRGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLLVESDLKIGQHKAKIEELRAHLLRWGFTTPDKKHQKEPPFLW >P153-8| codons 1-229 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDGNKWRKLVDFRELNKRTQDFWEVQLGIPHLAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPRGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLLVESDLKIGQHKAKIEELRAHLLRWGFTTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12P, K14R, I15V, R41K, D60E, Q61E, I62V, L63P, C67S, I72V |
| >P153-8| H02 | codons 1-99 | clone H02 PQITLWQRPLVPIRVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYE EVPIEISGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P153-8| codons 1-99 PQITLWQRPLVPIRVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYE EVPIEISGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |