<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10M, T12S, I15V, L19I, M36I, P39S, R41K, K45R, Y59C, H69K, L89M, I93L  
>SK107| codons 1-99
PQITLWQRPMVSIKVGGQIKEALLDTGADDTVLEEINLSGKWKPRMIGGIGGFIKVRQCD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, D177E, T200E, E204K, Q207E, V245E, K277R, T286A, E291D, V292I, I293V, S322A, D324E, G335D, N348S, R356K, M357R, G359T, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452I, V467I, S468T, D471E, H483Q, L491S, I495V, K512R, S519N, Q524E, K530R, A534S, A554S K30E
>SK107| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEEIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI
YQYMDDLYVGSDLEIGQHREKIEKLREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPAKELIAEIQKQGQDQWTYQIYQEPFKSLKTGKYAKRRTA
HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMAGVETFYVDGAANRETKIGKAGYVTDRGRQKVITLTETTNQKTELQ
AIQLALQDSGSEVNVVTDSQYALGIIQAQPDRSESELVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D6E, K14R, D25E, K34R, I72V, L74I, L101I, T112V, I113L, T124A, T125A, H171Q, V201I, T206S, T218I, L234I, D278A S283G, R284G
>SK107| codons 1-288
FLDGIEKAQEEHERYHSNWRAMASEFNLPPVVAREIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVIIVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVLHTDNGSN
FTSAAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEQLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGGQDED

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008