<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K7R, D25E, V31I, M50T, I72V, L74I, F100Y, L101I, T112V, S119P, T124A, T125Q, K136Q, F181S, V201I, T218I, K219Q, L234I, D278A D286N
>SK085| codons 1-288
FLDGIDRAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEATHGQVDCSPGI
WQLDCTHLEGKVIIVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGPN
FTSAQVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
SIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIQIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVASRQNED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, K14R, I15V, L19V, M36I, R41K, H69K, L89M, I93L  
>SK085| codons 1-99
PQITLWQRPLVSIRVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6K, V35T, T39E, S48T, K122E, I142V, K173T, D177E, T200A, Q207E, V245K, A272P, L282P, R284K, E291D, P294Q, K311Q, Q334S, G335D, R356K, M357R, G359T, V365I, K366R, T377Q, S379A, K385R, K390R, A400T, E404D I293A
>SK085| codons 1-426
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKPLKGTKALTDVAQLTEEAE
LELAENREILQEPVHGVYYDPSKDLIAEIQKQGSDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDIRQLTEAVQKIAQEAIVIWGRTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLW

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008