<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, D25E, V31I, I72V, F100Y, L101I, T112V, S119P, S123C, T124A, T125A, K136Q, V201I, A205S, T206S, T218L, I220D, D232G, L234I, D253E, K273Q, D278A S283G
>SK065| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGPN
FTCAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIISSDIQTKELQKQILKDQNFRVYYRDSRGPIWKGPAK
LLWKGEGAVVIQENSDIKVVPRRKAKIIRDYGQQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L5F, T12S, K14R, I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93L  
>SK065| codons 1-99
PQITFWQRPLVSIRVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QITIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        A33T, V35T, T39E, S48T, V60I, K122E, I142V, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, V245E, A272P, E291D, V292I, I293V, Q334N, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, I434M, V435T, A437V, L452I, S468T, L469I, D471E, H483Q, L491S, K512N, S519N, Q524E, K530R, A534S, A554S  
>SK065| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKTLTEICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPELVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMTGVETFYVDGAANRETKIGKAGYVTDRGRQKVVTITETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDNSESELVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008