<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    R20K, D25E, V31I, M50I, I72V, I84V, Y99H, F100Y, L101I, T112V, T124A, T125A, K136Q, I200V, V201I, T206S, T218I, L234I, A265V, R269K, D278A S283G
>SK023| codons 1-288
FLDGIDKAQEEHEKYHSNWKAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYVEAEVIPAETGQETAHYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERVIDIIASDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, E35D, M36I, N37S, R41K, H69K, L89M, I93L  
>SK023| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDISLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    Y188L   V35T, T39E, S48T, V60I, K122E, D123G, E138G, K166R, K173I, Q174K, D177E, V179T, R211K, V245Q, A272Q, T286A, E291D, V292I, I293V, Q334P, G335D, R356K, G359T, K366R, T377L, K390R, A400R, E404D, V435A, G436E, K451T, V466I, T470S, D471E, T477A, H483Q, L491S, S519N, K530R, A554K G231R, N306S
>SK023| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNGTPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRIKNPEITI
YQYMDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMRYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYQGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAESREILKEPVHGVYYDPSKDLIAEIQKQGPDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVRQLTEAVQKIALESIVIWGKTPKFRLPIQKETWERWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAEAETFYVDGAANRETTLGKAGYVTDRGRQKIVSLSETTNQKAELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLAWVPAHK
GIGGNEQVDKLVSKGIRKVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008