Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P146 | P146-16 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 16 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, V75M, M184V, L210W, T215Y | K219R | K103N | V108I | V35I, K43Q, E44D, V118I, D123E, I135T, K166R, I178M, E203K, Q207A, R211K, K223E, L228R |
| >P146-16| D01 | codons 1-229 | clone D01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKDSDEWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIKELRAHLWKWGFYTPDRKHQEEPPLRW >P146-16| G05 | codons 1-229 | clone G05 PISPIETVPVKLRPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKRTQDFWEVRLGIPHPGGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSINDETPGIRYQYNVLPQGWKGSPTIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIKELRAHLWKWGFYTPDRKHQEEPPFRW >P146-16| D02 | codons 1-229 | clone D02 PSSPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSLNNEAPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIEELRAHLLKWGFYTPDKKHQKEPPFLW >P146-16| D03 | codons 1-229 | clone D03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIKELRAHLWKWGFYTPDRKHQEEPPFRW >P146-16| G01 | codons 1-229 | clone G01 PISPIETVPVKLKPGMDGPKVKQWPLAEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIKELRAHLWKWGFYTPDRKHQEEPPLRW >P146-16| G08 | codons 1-229 | clone G08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELENDGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIKELRAHLWKWGFYTPDRKHQEEPPFRW >P146-16| G06 | codons 1-229 | clone G06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTRTLEPFRKQNPDMVI YQYVDDL*VGSDLEIGQHRTKIKELRAHLWKWGFYTPDRKHQEEPPFRW >P146-16| G02 | codons 1-229 | clone G02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIKELRAHLWKWGFYTPDRKHQEEPPLRW >P146-16| G07 | codons 1-229 | clone G07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNGTPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIKELRAHLWKWGFYTPDRKHQEEPPFRW >P146-16| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIKELRAHLWKWGFYTPDRKHQEEPPFRW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L63P |
| >P146-16| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P146-16| G06 | codons 1-99 | clone G06 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P146-16| G07 | codons 1-99 | clone G07 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P146-16| D01 | codons 1-99 | clone D01 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P146-16| D02 | codons 1-99 | clone D02 PQITLWQRPLVTIKIRGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P146-16| D03 | codons 1-99 | clone D03 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P146-16| G02 | codons 1-99 | clone G02 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P146-16| G01 | codons 1-99 | clone G01 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLGEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P146-16| G08 | codons 1-99 | clone G08 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P146-16| G05 | codons 1-99 | clone G05 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIEVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQNGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |