Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PS368 | PS368 | South Africa | 2008 | HIV1 | C | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, G16E, L19I, M36T, P39S, R41K, D60E, I62V, H69K, L89M, I93L |
| >PS368| codons 1-99 PQITLWQRPLVSIKVEGQIKEALLDTGADDTVLEETNLSGKWKPKMIGGIGGFIKVRQYE QVLIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L | E6D, K20R, V35T, E36A, T39E, V60I, K122E, D123N, K166R, K173A, T200A, Q207E, V245L, A272P, I274V, K281R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, V435A, A446S, N447H, K465R, V466I, V467I, D471E, T477A, H483L, L491S, S519N, K527N, K530R, V531I, A534S |
| >PS368| codons 1-540 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALTAICEELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPILLPEKDSWTVNDIQKLVGKLNWASQIYPGVKVKQLCRLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGASHRETKLGKAGYVTDRGRQRIISLTETTNQKAELQ AILLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKERIYLSWVPAHK |
References
| Author | Title | Citation |
| Matthews, PC | Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. | J Virol, 2008 |