Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P145 | P145-16 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 16 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219Q | Y188L | V35I, T69E, K102R, D123E, I178M, Q197H, I202V, Q207A, R211K, L228H |
| >P145-16| A06 | codons 1-229 | clone A06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKGTQDFWEVQLGIPHPAGLKGKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDVVI YQYVDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-16| A11 | codons 1-229 | clone A11 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNMLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-16| A08 | codons 1-229 | clone A08 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKRNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNRSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVASDLEIGHHRTKIEKLRAHLLKWGFFTPDQKHQKEPPFHW >P145-16| A12 | codons 1-229 | clone A12 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVT YQYVDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPEQKHQKEPPFHW >P145-16| A09 | codons 1-229 | clone A09 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALMEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDF*EVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSSAIFQSSMTKILEPFRKQNPDMVI YQYVDDLLVESDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-16| A04 | codons 1-229 | clone A04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-16| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-16| A07 | codons 1-229 | clone A07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKVKALIEICTELEKGGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, R41K, L63P, I64V, K70R, V77I |
| >P145-16| A06 | codons 1-99 | clone A06 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P145-16| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P145-16| A07 | codons 1-99 | clone A07 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P145-16| A04 | codons 1-99 | clone A04 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWEPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P145-16| A12 | codons 1-99 | clone A12 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P145-16| A11 | codons 1-99 | clone A11 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P145-16| A08 | codons 1-99 | clone A08 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P145-16| A09 | codons 1-99 | clone A09 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIVGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |