<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S17N, D25E, V31I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, G163E, H183R, V201I, I204V, T218I, L234I, D278A S283G
>PS206| codons 1-288
FLDGIDKAQEEHEKYHNNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIEQVRDQAEHLKTAVQMAV
FIRNFKRKGGIGGYSAGERIIDIVATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, K14R, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93L  
>PS206| codons 1-99
PQITLWQRPLVSIRVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K32R, V35T, T39K, S48T, V60I, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, D324E, Q334N, G335D, R356K, R358K, G359T, T377L, K390R, A400T, E404D, I434M, V435T, A437V, L452I, S468T, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554R  
>PS206| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALTEICKEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMKTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMTGVETFYVDGAANRETKIGKAGYVTDRGRQKVVTLTETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSRGIRKVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008