Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P145 | P145-67 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 19 |
| 3 | 3TC+AZT+EFV+IDV | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | Y188L | V35I, T69E, K102W, D123E, K173T, Q174K, I178M, I202V, Q207A, R211K, L228H |
| >P145-67| H02 | codons 1-229 | clone H02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEVCTELEKEGKISKIGPENPYNTPI FAIKKKDSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDMVI YQYMDDLLVGSDLEIGQHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-67| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDMVI YQYMDDLLVGSDLEIGQHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-67| H05 | codons 1-229 | clone H05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKGTQDFWEVQLGIPHPAGLKWKKSVTVLDVGDAHFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQGSMTKILEPFRTKNPDMVI YQYMDDLLVGSDLEIGQHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-67| H08 | codons 1-229 | clone H08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | K14R, R41K, L63P, I64V, K70R, V77I |
| >P145-67| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P145-67| H02 | codons 1-99 | clone H02 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNVIGRNLLTKIGCTLNF >P145-67| H05 | codons 1-99 | clone H05 PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNPMTQLGCTLNF >P145-67| H08 | codons 1-99 | clone H08 PQITLWQRPLVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPVEICGHRAICTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |