Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P145 | P145-0 | U.S. | 1996 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, T215F | K219Q | K20R, V35I, D123E, I178M, Q197H, I202V, Q207A, R211K, L228H |
| >P145-0| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-0| H01 | codons 1-229 | clone H01 PISPIETVPVKLKPGIDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-0| H10 | codons 1-229 | clone H10 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-0| H07 | codons 1-229 | clone H07 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQNFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-0| H02 | codons 1-229 | clone H02 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGHHRTKIEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-0| H12 | codons 1-229 | clone H12 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTGLEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGHHRTKIEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-0| H06 | codons 1-229 | clone H06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, R41K, L63P, I64V, K70R |
| >P145-0| H01 | codons 1-99 | clone H01 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P145-0| H10 | codons 1-99 | clone H10 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P145-0| H07 | codons 1-99 | clone H07 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P145-0| H02 | codons 1-99 | clone H02 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P145-0| H12 | codons 1-99 | clone H12 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P145-0| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P145-0| H06 | codons 1-99 | clone H06 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |