Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P145 | P145-55 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 19 |
| 3 | 3TC+AZT+EFV+IDV | 36 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | Y188L | V35I, T69E, K102R, V106I, D123E, I178M, Q197H, I202V, Q207A, R211K, L228H |
| >P145-55| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-55| G08 | codons 1-229 | clone G08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQTEPPFHW >P145-55| G03 | codons 1-229 | clone G03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-55| G07 | codons 1-229 | clone G07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKRNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVGELRAHLLKWGFFTPDQKHQKEPPFHW >P145-55| G06 | codons 1-229 | clone G06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPI FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLLVGSDLEIGHHRTKVGELRAHLLKWGFFTPDQKHQKEPPFHW >P145-55| G05 | codons 1-229 | clone G05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDMVI YQYMDDLLVGSDLEIGQHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-55| G02 | codons 1-229 | clone G02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKGGFFTPDQKHQKEPPFHW >P145-55| G09 | codons 1-229 | clone G09 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSERRRKLVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI CQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW >P145-55| G04 | codons 1-229 | clone G04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L | L10R, K14R, R41K, L63P, I64V, K70R, V77I |
| >P145-55| codons 1-99 PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P145-55| G03 | codons 1-99 | clone G03 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD HIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >P145-55| G05 | codons 1-99 | clone G05 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMNLPGKWKPKLIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >P145-55| G06 | codons 1-99 | clone G06 PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLMTQIGCTLNF >P145-55| G07 | codons 1-99 | clone G07 PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P145-55| G08 | codons 1-99 | clone G08 PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLMTQLGCTLNF >P145-55| G09 | codons 1-99 | clone G09 PQITLWQRPRVTIRIGGQLKEALLDTGADGTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVSIIGRNLLTQIGCTLNF >P145-55| G02 | codons 1-99 | clone G02 PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPVGICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P145-55| G04 | codons 1-99 | clone G04 PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |