<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E10X, D25E, K34R, M50I, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, E157D, D167E, V201I, I208M, K215R, L234I, S255G, D278A S283G
>PS140| codons 1-288
FLDGIDKAQXEHEKYHSNWRAMASEFNLPPVVAREIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIIIVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKDLKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDMQTKELQRQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNGDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19V, K20R, E35D, M36I, R41K, H69K, L89M, I93L  
>PS140| codons 1-99
PQITLWQRPLVSIKVGGQVREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39N, S48T, V60I, K122E, K166R, K173A, Q174T, D177E, T200A, Q207A, F214L, L228H, V245Q, A272S, K277R, K287R, E291D, V292I, I293V, P294T, Q334D, G335D, R356K, M357R, G359T, T377L, K390R, E399N, A400I, E404D, V435A, L452M, V458I, D471E, H483Q, L491S, S519N, Q520K, K527E, K530R, A534S, A554S  
>PS140| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRATNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLRWGLTTPDKKHQKEPPFHWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGTRALTDIVTLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWNIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKMGKAGYITDRGRQKVVSLTETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNKIIEQLIEKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008