<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D25E, M50I, Q95R, F100Y, L101I, T112I, S119P, T125A, K136Q, G163V, H171R, V201I, T218I, L234I, R269K, D278A S283G
>PS126| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLPPVVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGRETAYYILKLAGRWPVKIIHTDNGPN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIVQVRDQAERLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, K14R, I15V, L19V, K20R, E35D, M36I, R41K, H69K, L89M, I93L  
>PS126| codons 1-99
PQITLWQRPLVSIRVGGQVREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        I5V, V35T, E36A, T39E, S48T, K122E, D123S, S162C, K166R, K173T, Q174K, D177E, T200A, R211K, F214L, V245Q, D250E, A272K, K277R, E291D, V292I, I293V, V314I, Q334N, G335D, R356K, G359T, L368P, T377L, K390R, A400I, E404D, V435A, V466I, S468T, T470S, D471E, H483Q, L491S, K512R, L517I, S519N, K527N, K530R, A534S, A554S  
>PS126| codons 1-560
PISPVETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRTKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYKGIKVRQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPIHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQPTEAVQKIALESIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKIVTLSETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDRSESEIVNQIIEQLINKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008