<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E10X, D25E, M50I, Q95R, F100Y, L101I, T112I, S119P, T125A, K136Q, G163V, H171R, V201I, T218I, L234I, R269K, D278A S283G
>PS125| codons 1-288
FLDGIDKAQXEHEKYHSNWRAMASEFNLPPVVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGRETAYYILKLAGRWPVKIIHTDNGPN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIVQVRDQAERLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I13V, K14R, I15V, L19I, M36I, R41K, H69K, T74S, L89M, I93L  
>PS125| codons 1-99
PQITLWQRPLVSVRVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6K, V35T, E36G, T39E, S48T, V60I, K122E, D123S, S134G, I135V, S162Y, K173A, Q174K, D177E, T200A, Q207E, R211K, V245K, A272P, K275R, Q278N, T286A, E291D, V292I, D324E, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, I434M, V435A, G436E, A437V, L452I, S468T, D471E, T477A, H483Q, L491P, I495V, S519N, Q524E, K530R, A534S, A554S Y144D, T472P
>PS125| codons 1-560
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTGICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPGVNNETPGIRDQYNVLPQGWKGSPAIFQYSMTKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKNLCKLLRGAKALTDIIPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMAEVETFYVDGAANRETKIGKAGYVTDRGRQKVVTLTEPTNQKAELQ
AIQLALQDSGPEVNVVTDSQYALGIIQAQPDKSESELVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008